TOBRAMYCIN

                                            TOBRAMYCIN

                 STERILE OPHTHALMIC SOLUTION AND OINTMENT

 DESCRIPTION:

Tobramycin is a generic name, available in many trade names among these is Tobrex which is manufactured by Alcon a Novartis company. It is a sterile ophthalmic antibiotic formulation prepared specifically for topical therapy of external infections. This product is supplied in solution and ointment forms. 

Each ml of solution contains Tobramycin 0.3% (3mg/ml), inactives and purified water and Benzalkonium chloride 0.01% as a preservative.

Each gram of ointment contains Tobramycin 0.3% (3mg/g), mineral oil, petrolatum base and chlorobutanol 0.5% as a preservative.

Tobramycin is a water soluble aminoglycoside antibiotic active against a wide variety of gram negative and gram positive ophthalmic pathogens.

CLINICAL PHARMACOLOGY:

It is active against susceptible strains of the following microorganisms; Staphylococci, Streptococci, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabili, Haemophilus influenza and many others.

INDICATIONS:

it is used in the treatment of external infections of the eyes and its adnexa caused by susceptible bacteria. it is safe and effective for use in children.

CONTRAINDICATIONS:

• Hypersensitivity

ADVERSE REACTIONS:

• Localized ocular toxicity
• hypersensitivity
• lid itching and swelling
• conjunctival erythema
• it produces less adverse effects.

OVER-DOSAGE:

• Punctuate keratitis
• erythema
• increased lacrimation
• edema and lid itching

DOSAGE AND ADMINISTRATION:

Solution:

• In mild to moderate disease, instill one or two drops into the affected eyes every four hours.
• In severe infections, instill two drops into eyes hourly until improvement.

Ointment:

• In mild to moderate disease, apply a 1.5 cm ribbon into the affected eyes two or three times per day.
• In severe infections, instill a 1.5 cm ribbon into the affected eyes every three to four hours until improvement.